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Achieving population-level impacts within Feed the Future will require scaling up—ensuring that more people benefit from access to and effective use of agricultural technologies. This process starts with research and innovation to generate technologies that can benefit smallholder farm families and other entrepreneurs along the value chain. At the 2014 Feed the Future Global Forum, Julie Howard, Chief Scientist for the USAID Bureau for Food Security, guided an interactive discussion with a diverse set of experts who are leading some of the most interesting and innovative scaling experiments in the world. Participants learned about innovation and changing expectations of researchers in developing technologies that can eventually be scaled; the challenges of scaling up the adoption of improved maize varieties and other technologies that could dramatically increase smallholder farmer yields and incomes in Africa; the role of small businesses and the service provider model in sustainably scaling up the adoption of small-scale farm machinery; and how a new model of partnership in Ethiopia, the Agricultural Transformation Agency, is working with a range of public and private sector organizations to find and scale innovative solutions to intractable problems.